Pharmacology and Therapeutics
Dean Tang, PhD
Department of Pharmacology and Therapeutics
Roswell Park Cancer Institute
The Department of Pharmacology and Therapeutics is comprised of 15 independent research laboratories with a collective focus on a multidisciplinary approach to experimental cancer therapeutics. Departmental faculty have varied and overlapping research goals that can be broadly subdivided into three categories:
1) Identification of novel molecular targets for therapeutic intervention;
2) Characterizing the mechanisms of action and preclinical development of novel drugs;
3) Optimizing the use of existing drugs through combination therapy, re-purposing, imaging, and identification of patient sub-populations and cancer types most likely to respond favorably.
Research in the department exploits state-of-the-art experimental approaches in genomics, genetics, molecular biology, cell biology, imaging, biochemistry, and animal modeling to accomplish these goals. Departmental researchers collaborate frequently with each other, and with other scientists at RPCI and elsewhere, to leverage expertise from a variety of disciplines. This fertile environment is further enriched by participation of departmental researchers in RPCI Disease Site Research Groups, University at Buffalo graduate training programs, RPCI Comprehensive Cancer Support Grant Programs, interactions with clinical colleagues at RPCI and elsewhere, and collaborations with partners in the pharmaceutical industry.