Small Molecule Screening Shared Resource

The Small Molecule Screening Shared Resource (SMS) provides investigators with the possibility of screening chemical libraries in a variety of readout systems for new prospective diagnostic and therapeutic compounds and research tools.

Researchers at RPCI and other biomedical institutions in the Buffalo area can get assistance with the design and execution of chemical screenings in a variety of readout systems. Located on the RPCI campus, the SMSR provides easy access to investigators during all stages of the screening project including:

  • Design and adjustment of readout
  • High throughput screening
  • Hit selection and confirmation
  • Preliminary hit characterization and structure-activity relationship (SAR) analysis

The collection of chemicals at SMSR totals more than 110,000 compounds. Sophisticated automated liquid handling equipment is used to ensure accurate delivery of this library in both the 96- and 384-well format, and our detection equipment allows for screening using either cell based or biochemical assays.


Roswell Park Cancer Institute
Small Molecule Screening Shared Resource
Center for Genetics and Pharmacology, Room L1-215
Elm and Carlton Streets
Buffalo, New York 14263

Operating Schedule

Monday – Friday, 8 a.m. – 5 p.m.