2008 Pharmacology and Therapeutics Publications

Anne N, Rajput A, Bullard Dunn K, Litwin A. Idiopathic pneumatosis intestinalis of the small intestine. Am Surg, 74:1127-1129, 2008.

Bagnyukova TV, Tryndyak VP, Montgomery B, Churchwell MI, Karpf AR, James SR, Muskhelishvili L, Beland FA, Pogribny IP. Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. Carcinogenesis, 29: 638-646, 2008.

Bernacki RJ. Commentary: Metronomic chemotherapy and tumor immunomodulation. Cancer Biol Ther, 7: 4, 2008.

Boult JKR, Hughes S, Campbell MJ, Tselepis C. Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network. British Journal of Cancer, 98:1985-1992, 2008.

Camoriano M, Morey Kinney SR, Moser MT, Foster BA, Mohler JL, Trump DL, Karpf AR, Smiraglia DJ. Phenotype-specific CpG island methylation events in a murine model of prostate cancer. Cancer Res, 68:4173-7182, 2008.

Campbell MJ, Carlberg C, Koeffler HP. A role for PPARγ in cancer therapy. In "PPARs: A Double-Edged Sword in Cancer Therapy" PPAR Research, 2008:314974, 2008.

Coward JK , McGuire JJ. Mechanism-Based Inhibitors of Folylpoly-g-glutamate Synthetase and g-Glutamyl Hydrolase: Control of Folylpoly-g-glutamate Homeostasis as a Drug Target. Vitamins Hormones, 79:347-373, 2008.

Fakih MG, Bullard Dunn K, Yang GY, Pendyala L, Toth K, Andrews C, Rustum YM, Ross ME, LeVea C, Puthillath A, Park Y-M, Rajput A. A Phase II study of weekly intravenous oxaliplatin combined with oral daily capecitabine and radiotherapy with biologic correlates in neoadjuvant treatment of rectal adenocarcinoma. Int J Radiat Oncol Biol Phys, 72:650-657, 2008.

Fang XP, Rodabaugh K, Penetrante R, Wong M, Wagner T, Sait S, Mhawech-Fauceglia P. Desmoplastic small round cell tumor (DSRCT) with ovarian involvement in 2 young women. Applied Immunohistochemistry & Molecular Morphology, 16: 94-99, 2008.

Furimsky AM, Green CE, Sharp LEH, Catz P, Adjei AA, Parman T, Kapetanovic IM, Weinshilboum RM, Iyer LV. Effect of resveratrol on 17 beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1. Drug Metabolism and Disposition, 36: 129-136, 2008.

Furth AF, Mandrekar SJ, Tan AD, Rau A, Felten SJ, Ames MM, Adjei AA, Erlichman C, Reid JM. A limited sample model to predict area under the drug concentration curve for 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite 17-(amino)-17-demethoxygeldanomycin. Cancer Chemotherapy and Pharmacology, 61: 39-45, 2008.

Godoy A, Watts A, Sotomayor P, Montecinos VP, Huss WJ, Onate SA, Smith GJ. Androgen receptor is causally involved in the homeostasis of the human prostate endothelial cell. Endocrinology, 149:2959-2969, 2008.

Gonzalez-Fernandez F, Ghosh D. Focus on molecules: Interphotoreceptor retinoid-binding protein (IRBP). Experimental Eye Research, 86: 169-170, 2008.

Javle M, Pande AU, Iyer RV, Rani A, Maddipatla S, Yang GY, Nwogu CE, Black JD, Levea CM. Epidermal growth factor receptor (EGFR)-directed therapy in esophageal cancer. Oncology, 73:281-289, 2008.

Kaplan-Lefko PJ, Sutherland BW, Evangelou AI, Hadsell DL, Barrios RJ, Foster BA, Demayo F, Greenberg NM.  Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis.  Oncogene, 27:2868-76, 2008.

Karipparettu BA, Zubairy S, Konduri SD, Liu W, Rokavec M, van der Kuip H, Hoppe R, Fritz P, Schroth W, Abele I, Das GM, Oesterreich S, Brauch H. Estrogen-mediated down-regulation of CD24 in breast cancer cells. International Journal of Cancer, 123: 66-72, 2008.

Karpf AR. Cancer Germline (CG) Antigens.   Encyclopedia of Cancer, 2nd Edition, M Schwab, Ed: Springer-Verlag, Heidelberg, Berlin, Heidelberg, New York, 2008, p. 478-479.

Karpf AR, Bai S, James SR, Mohler JL, Wilson EM. Promoter DNA hypomethylation and cyclic AMP regulation of androgen receptor coregulator MAGE-11 in prostate cancer. Molecular Cancer Research, (In Press).

Kramer DL, Diegelman P, Jell J, Vujcic S, Merali S, Porter CW. Polyamine acetylation modulates polyamine metabolic flux--a prelude to broader metabolic consequences. J Biol Chem, 283: 4241-4251, 2008.

Liu W, Ip MM, Podgorsak MB, Das GM. Disruption of estrogen receptor a-p53 interaction in breast tumors: A novel mechanism underlying the anti-tumor effect of radiation therapy. Breast Cancer Research and Treatment, (In press). [Epub 5/16/08]

Ma Y, Yu W-D, Hershberger PA, Flynn G, Kong R-X, Trump DL, Johnson CS. 1,25D3 potentiates the anti-tumor activity of cisplatin through increased p73 and enhanced apoptosis in squamous cell carcinoma model system. Mol Cancer Ther, 7:3047-3055, 2008.

Menezes RJ, Cheney RT, Husain A, Tretiakova M, Loewen G, Johnson CS, Jayaprakash VV, Moysich KB, Salgia R, Reid ME. Vitamin D receptor expression in normal, premalignant and malignant human lung tissue. Cancer Epidemiol Biomarkers Prev, 17:1104-1110, 2008.

Meng X, Shoemaker SF, McGee SO, Ip MM. t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in HER2/ErbB2 mice through activation of both proliferative and survival pathways. Carcinogenesis, 29:1013-1021, 2008.

Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR. Stage-specific alterations of Dnmt expression and DNA methylation during prostate cancer progression in the TRAMP model. Molecular Cancer Research, 6:1365-1374, 2008.

Ojima I, Chen J, Linag S, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallerger D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St. Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ. Design, synthesis and biological evaluation of new-generation taxoids. J. Med.Chem., 51:3203-3221, 2008.

Ong ES, Alassas M, Dunn KB, Rajput A. Colorectal cancer surgery in the elderly: acceptable morbidity? American Journal of Surgery, 195: 344-348, 2008.

Ou L, Wu Y, Ip C, Meng X, Hsu Y-C, Ip MM. Apoptosis induced by the t10,c12 isomer of conjugated linoleic acid in mammary tumors cells is mediated through an atypical endoplasmic reticulum stress response. J. Lipid Res, 49:985-994, 2008.

Rai K, Huggins I, James SR, Karpf AR, Jones DA, Cairns BR. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and Gadd45. Cell, 135:1201-1212, 2008.

Raj D, Liu T, Samadashwily G, Li F, Grossman D. Survivin repression by p53, Rb, and E2F2 in normal human melanocytes. Carcinogenesis, 29: 194-201, 2008.

Rajput A, Dominguez I, Rose R, Beko A, LeVea C, Sharratt E, Mazurchuk R, Hoffman RM, Brattain MG, Wang J.  Characterization of HCT 116 human colon cancer cells in an orthotopic model.  J. Surg. Res., 147:276-281, 2008.

Rassnick KM, Muindi JR, Johnson CS, Balkman CE, Ramnath N, Yu W-D, Engler KL, Page RL, Trump DL.  In Vivo and In Vitro evaluation of combined calcitriol and cisplatin in dogs with spontaneously occurring tumors. Cancer Chemother Pharmacol, 62:881-891, 2008.

Schaefer AL, Greenberg EP, Oliver CM, Oda Y, Huang JJ, Bittan-Banin G, Peres CM, Schmidt S, Juhaszova K, Sufrin JR, Harwood CS. A new class of homoserine lactone quorum sensing signals. Nature, 454:595-599, 2008.

Sher T, Dy GK, Adjei AA. Small cell lung cancer. Mayo Clinic Proceedings, 83: 355-367, 2008.

Siu KKW, Lee JE, Sufrin JR, Moffatt B, McMillan M, Cornell KA, Isom C, Howell PL. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases. J Mol Biol, 378: 112-128, 2008.

Smith R, Hicks D, Tomljanovich P, Lele SB, Rajput A, Bullard Dunn K.  Adenocarcinoma arising from chronic perianal Crohn’s disease: case report and review of the literature. American Surgeon, 74: 59-61, 2008.

Sotomayor P, Godoy A, Smith GJ, Huss WJ. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate, 69:401-410, 2008.

Sufrin JR, Spiess AJ, Marasco CJ, Rattendi D, Bacchi CJ.  Novel trypanocidal analogs of 5'-(methylthio)adenosine. Antimicrobial Agents and Chemotherapy, 52: 211-219, 2008.

Thorne J, Campbell MJ.  The Vitamin D Receptor in Cancer. Proc Nutr Soc, 67: 115-127, 2008.

Wang J, Rajput A, Kan JLC, Rose R, Kuropatwinski K, Hauser J, Beko A, Gibson NW, Brattain MG.  Knockdown of RON tyrosine kinase leads to reduced metastasis in an orthotopic model of human colon carcinoma cells. J Biol Chem, (In press).

Wang J, Kulaylat M, Rockett H, Hassett J, Rajput A, Bullard Dunn K, Dayton M. Should total number of lymph nodes be used as a quality of care measure for stage III colon cancer? Ann Surg, (In Press).

Woloszynska-Read A, Mhawech-Fauceglia P, Yu J, Odunsi K, Karpf AR. Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer. Clin Ca Research, 14:3283-3290, 2008.

Yang J, Li Y, Khoury T, Ramnath N, Goodrich DW, Tan DF. Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. Annal Clin Lab Sci, 38:105-112, 2008.

Yu X, Baek S-H, Kang HP, Foster BA, Park YM. Elevated MMP2 activity and invasiveness in TRAMP prostate cancer cells metastasized to the bone: Aberrant expression of PDGF-C and augmented PDGF-Akt-NK-kB signaling pathway. Cancer Research, (In press).

Zhu N, Gu L, Li F, Zhou M. Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular Cancer Therapeutics, 7:1101-1109, 2008.