2005 Pharmacology and Therapeutics Publications

Antony S, Kohlhagen G, Jayaraman M, Cao S, Durrani F, Rustum YM, Cushman M, Pommier Y. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-111-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol. Pharm. 67(2):523-530, 2005

Antony S, Kohlhagen G, Agama K, Jayaraman M, Cao S, Durrani F, Rustum YM, Cushman M, Pommier Y. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-111-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol. Pharm. 67(2):523-530, 2005

Cao S, Durrani FA, Rustum YM. Synergistic antitumor activity of capecitabine in combination with irinotecan against human tumor xenografts. Clin Colorectal Cancer 4(5):336-343, 2005

Ewens AD, Mihich E, Ehrke MJ. Fluorouracil Plus Leucovorin induces submandibular salivary gland enlargement in rats. Toxicol Pathol 33:507-515, 2005

Geney R, Sun L, Pera P, Bernacki RJ, Xia S, Horwitz SB, Simmerling CL, Ojima I. Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. Chemistry & Biology 12:1-10, 2005

Hu YP, Venkateswarlu S, Sergina N, Howell G, St Clair P, Humphrey LE, Li W, Hauser J, Zborowska E, Willson JK, Brattain MG. Reorganization of ErbB family and cell survival signaling following knockdown of ErbB2 in colon cancer cells. J. Biol. Chem. 2005 May 11; 280:27383-92, 2005.

Huang W, Zhao S, Ammanamanch S, Brattain M, Venkatasubbaro K, Freeman, J. Trichostatin A induces TGFƒÒ type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1/NFY complex J. Biol. Chem. 280:11:10047-10054, 2005

Jarvinen A, Grigorenko N, Khomutov AR, Hyvonen MT, Uimari A, Vepsalainen J, Sinervirta R, Keinanen TA, Vujcic S, Alhonen L, Porter CW, Janne J. Metabolic stability of Ą-methylated polyamine derivatives and their use as substitutes for the natural polyamines. J Biol. Chem. 280(8):6595-6601, 2005

Kondoh H, Lleonart M, Wang J, Carnero A and Beach D. Cellular life span and the Warburg effect. Cancer Res. 65(1):177-185, 2005

Lakhman SS, Ghosh D, Blanco JG. Functional significance of a natural allelic variance of human carbonyl reductase 3 (CBR3). Drug Metab. Dispos. 33(2):254-257, 2005

Lee SO, Nadiminty N, Wu XX, Lou W, Dong Y, Ip C, Onate SA, Gao AC. Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells. Cancer Res 65(8):3487-3492, 2005

Li Y, Wang X, Zhang X, Goodrich DW. Human hHpr1/p84Thoc1 regulates transcriptional elongation and physically links RNA Polymerase II and RNA processing factors. Mol. Cell. Biol. 25:4023-4033, 2005

Li F. Role of survivin and its splice variants in tumorigenesis. Br J Cancer 92(2):212-216, 2005

Li F, Ling X, Huang H, Brattain L, Apontes P, Wu J, Binderup L, Brattain MG. Differential regulation of survivin expression and apoptosis by vitamin D3 in two isogenic MCF-7 breast cancer cell sublines. Oncogene 24(8): 1385-1395, 2005

Li F, Yang J, Ramnath N, Javle MM, Tan D. Nuclear and/or cytoplasmic expression of survivin: What is the significance? Int J Cancer 114(4): 509-512, 2005.

Ling X, Tan D, Ramnath N, Yang J, Younis T, Slocum HK, Yang L, Zhou M, Li F. Differential expression of survivin-2B and survivin-ƒ´Ex3) is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC). Lung Cancer, 49:353-61, 2005.

McHugh MM, Gawron LS, Matsui S-I, Beerman TA. The DNA damaging enediyne C-1027 induces chromosomal aberrations, altered cell cycle progression and telomere dysfunction. Cancer Res. 65:5344-5351, 2005

Mihich E, Jaenisch. Sixteenth Annual Pezcoller Symposium: Stem cells and epigenesis in Cancer. Cancer Res. 64(22):8474-8477, 2005

Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Brennan JA, Neale G, Porter CW, Kramer DL, Cleveland JL. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell 7:1-12, 2005

Ojima I, Borella CP, Wu XY, Bounaud PY, Oderda CF, Sturm M, Miller ML, Chakravarty S, Chen J, Huang Q, Pera P, Brooks TA, Baer MR, Bernacki RJ. Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents. J.Med.Chem. 48(6):2218-2228, 2005

Philips BJ, Chang AY, Dervan PB, Beerman TA. DNA damage effects of a polyamide-CBI conjugate in SV40 virions. Mol. Pharm 67:877-822, 2005

Samlowski WE, Leachman SA, Wade M, Cassidy P, Porter-Gill P, Busby L, Wheeler R, Jones DA, Karpf AR. Evaluation of a 7-day continuous intravenous infusion of decitabine (5-aza-2'-deoxycytidine): Inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol. 23:3897-3905, 2005

Sawhney RS. Immunological identification of types I and type III collagen in bovine lens epithelium and its anterior lens capsule. Cell Biology International 29:133-137, 2005

Singh SV, Srivastava SK, Choi S, Lew, KL, Xiao D, Zeng Y, Johnson CS, Trump DL, Lee YJ. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem 280:19911-19924, 2005

Song L, James SR, Kazim L, Karpf AR. A rapid, sensitive, and specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Chem. 77(2):504-510, 2005

Song L, James SR, Kazim L, Karpf AR. A rapid, sensitive, and specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Chem. 77(2):504-510, 2005

Spengler ML, Kennett SB, Moorefield KS, Simmons SO, Brattain MG, Horowitz JM. Sumoylaton of internally initiated Sp3 isoforms regulates transcriptional repression via a trichostatin A-insensitive mechanism. Cell Signal 17:153-166, 2005

Trump DL, Muindi J, Johnson CS, Hershberger PA. Clinical development of calcitriol and calcitriol analogs in oncology: Progress and considerations for future development. In: Vitamin D (2nd edition). Feldman, Pike & Glorieux (eds), Chapter 97, pp. 1741-1749, 2005

Tucker JM, Murphy JT, Kisiel N, Diegelman P, Barbour KW, Davis C, Medda M, Alhonen L, Janne J, Kramer DL, Porter CW, Berger FG. Potent modulation of intestinal tumorigenesis in ApcMin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res 65:5390-5398, 2005

Wang Y, Feng L, Said M, Balderman S, Fayazi Z, Liu Y, Ghosh D, Gulick AM. Analysis of the 2.0 A Crystal Structure of the Protein-DNA Complex of the Human PDEF Ets Domain Bound to the Prostate Specific Antigen Regulatory Site. Biochemistry 44(19):7095-7106, 2005

Weebadda, WKC, Jackson TJ, Lin AW. Expression of p16 variants in senescent human fibroblasts independent of protein phosphorylation. J. Cellular Biochemistry, 23:3897-905, 2005.

Wu J, Ling X, Pan D, Apontes P, Song L, Liang P, Altieri DC, Beerman T, Li F. Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence selective DNA-binding antitumor agent, hedamycin: evidence of survivin downregulation associated with drug sensitivity. J Biol Chem 280(10): 9745-51, 2005